Lamivudine and Zidovudine (AZT): quick facts and practical advice

If you’ve been prescribed lamivudine and zidovudine, you’re looking at two well-known antiretroviral drugs used to treat HIV. They work together as nucleoside reverse transcriptase inhibitors (NRTIs), which block the virus from copying its genetic material. That keeps your viral load lower and protects your immune system when taken correctly.

Usual dosing many doctors use: lamivudine is often 150 mg twice daily or 300 mg once daily, while zidovudine commonly comes as 300 mg twice daily. A common combo tablet (Combivir) pairs 300 mg zidovudine with 150 mg lamivudine for twice-daily use. Always follow the exact dose your clinician gives you—don’t swap these numbers on your own.

What to watch for: side effects and monitoring

Both drugs are generally effective but can cause side effects. Expect possible nausea, headache, fatigue, and sometimes sleep problems. Zidovudine is more linked to blood issues like anemia and low white blood cells, so regular blood counts are needed. Rare but serious problems include liver injury and lactic acidosis—your doctor should check liver tests and ask about symptoms like unexplained stomach pain, deep tiredness, or rapid breathing.

If you notice heavy bruising, persistent fever, or shortness of breath, contact your healthcare team. These drugs can interact with other medicines that affect the bone marrow or liver, so always list every medication, supplement, and herbal product you use.

How to use them safely and stay effective

Adherence matters. Missing doses makes resistance more likely and cuts the drugs’ benefit. Try simple routines: set phone alarms, use a pill box, or sync doses with daily habits like meals. If side effects make you skip pills, call your provider—often small adjustments or supportive meds can help.

Never stop suddenly without medical advice. Your clinician may switch or phase drugs to avoid resistance and manage side effects. Pregnant people are sometimes prescribed zidovudine to lower transmission risk to the baby—if this applies, discuss timing and monitoring closely with your obstetric team.

Thinking of buying lamivudine or zidovudine online? Only use pharmacies that require a prescription, display clear contact details, and have verifiable reviews. Avoid prices that look too good to be true. Check shipping rules for your country and if the pharmacy provides batch numbers or manufacturer info on the package. If you’re unsure about a site, ask your clinician for a trusted pharmacy recommendation.

Store tablets at room temperature, away from moisture and direct heat. Keep medications in their original packaging so you can check batch numbers and expiration dates.

If you have questions about side effects, interactions, or where to buy safely, talk to your healthcare provider or pharmacist. They can give advice tailored to your health and local rules. Staying informed and sticking to your plan gives you the best outcome with these medications.